P-type ATPase ion pumps exist in almost all cell membranes, pushing the ion against its concentration gradient across the cell membrane. Structural studies have made tremendous progress in recent years and we now know a lot about what is inside the ion pump, but it is unclear how they collect ions on one side and release them on the other. Now that Nicolás Reyes and David Gadsby got a working paper on ion pumps by decoupling the control gate of the Na +, K + -ATP enzyme's pump ion channel by using the marine toxin palytoxin, turning the pump into a cation channel New point of view. Outside the cell, the ion channel begins with a deep, wide porch that suddenly narrows to form a cation-selective filter consisting of acidic side chains. Strikingly, reversing the negative charge of only one of them changes the channel from the cation-selective channel to the anion-selective channel.
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